The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SGMS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SGMS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SGMS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:50,417,772–50,418,603 | 206.9 kb | Distal (>10kb) Multiome HiCAR | 592 | |
| chr10:50,525,999–50,526,990 | 98.9 kb | Distal (>10kb) Multiome | 97 | |
| chr10:50,527,119–50,527,948 | 97.5 kb | Distal (>10kb) Multiome | 184 | |
| chr10:50,552,393–50,553,104 | 72.4 kb | Distal (>10kb) Multiome HiCAR | 283 | |
| chr10:50,563,679–50,564,552 | 61.1 kb | Distal (>10kb) Multiome | 262 | |
| chr10:50,614,420–50,615,012 | 8.9 kb | Proximal (<10kb) | 213 | |
| chr10:50,621,826–50,626,107 | 513 bp | At TSS Multiome | 1163 | |
| chr10:50,629,879–50,630,062 | 5.9 kb | Proximal (<10kb) | 31 | |
| chr10:50,739,446–50,740,529 | 114.8 kb | Distal (>10kb) Multiome | 635 | |
| chr10:50,787,771–50,788,455 | 162.9 kb | Distal (>10kb) Multiome | 88 |
Genomic view of the SGMS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.