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DE-4.24

Submodule 13 genes

Extracellular matrix and cell adhesion proteins

This module contains 13 genes including HSPG2, PKP2, LAMB1, CACNB2, and MTHFD1L, with enrichment in extracellular matrix organization, cell adhesion, and basement membrane components. Knockdown of SOX11 and SOX4 activates this module. No repressing transcription factors were identified for this module.

Key terms: actin-mediated cell contraction cardiac conduction membrane depolarization during AV node cell action potential dicarboxylic acid biosynthetic process Notable genes: HSPG2 PKP2 LAMB1 CACNB2 MTHFD1L PLEKHA7 MPPED2 TBL1Y Top TFs: SOX11 SOX4

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (10)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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