The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPFIBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPFIBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPFIBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:27,243,875–27,245,004 | 279.9 kb | Distal (>10kb) Multiome | 897 | |
| chr12:27,332,152–27,333,788 | 191.2 kb | Distal (>10kb) Multiome | 640 | |
| chr12:27,347,364–27,348,398 | 176.1 kb | Distal (>10kb) Multiome | 160 | |
| chr12:27,515,746–27,515,972 | 8.2 kb | Proximal (<10kb) | 57 | |
| chr12:27,521,059–27,521,607 | 2.5 kb | Proximal (<10kb) | 224 | |
| chr12:27,521,881–27,522,535 | 1.6 kb | Proximal (<10kb) | 128 | |
| chr12:27,523,289–27,524,726 | 24 bp | At TSS Multiome | 792 | |
| chr12:27,525,382–27,525,777 | 1.2 kb | Proximal (<10kb) | 139 | |
| chr12:27,710,267–27,711,621 | 186.7 kb | Distal (>10kb) Multiome | 1000 | |
| chr12:27,779,439–27,781,351 | 256.0 kb | Distal (>10kb) Multiome | 834 |
Genomic view of the PPFIBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.