FGF8

fibroblast growth factor 8 | AIGF

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

Member of: DE-4 DE-4.23 Developmental clusters: GC2

Biological processes 49 terms

anatomical structure morphogenesis (GO:0009653)bone development (GO:0060348)central nervous system neuron development (GO:0021954)chemoattractant activity (GO:0042056)cytoplasm (GO:0005737)dopaminergic neuron differentiation (GO:0071542)dopaminergic neuron differentiation (GO:0071542)dorsal/ventral axon guidance (GO:0033563)dorsal/ventral pattern formation (GO:0009953)epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)external side of plasma membrane (GO:0009897)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)fibroblast growth factor receptor signaling pathway (GO:0008543)fibroblast growth factor receptor signaling pathway (GO:0008543)fibroblast growth factor receptor signaling pathway (GO:0008543)forebrain neuron development (GO:0021884)gastrulation (GO:0007369)gonad development (GO:0008406)growth factor activity (GO:0008083)growth factor activity (GO:0008083)growth factor activity (GO:0008083)mesonephros development (GO:0001823)metanephros development (GO:0001656)motor neuron axon guidance (GO:0008045)negative regulation of cardiac muscle tissue development (GO:0055026)neuroepithelial cell differentiation (GO:0060563)neurogenesis (GO:0022008)odontogenesis (GO:0042476)outflow tract septum morphogenesis (GO:0003148)outflow tract septum morphogenesis (GO:0003148)positive chemotaxis (GO:0050918)positive regulation of MAPK cascade (GO:0043410)positive regulation of cell differentiation (GO:0045597)positive regulation of cell population proliferation (GO:0008284)positive regulation of cell population proliferation (GO:0008284)positive regulation of gene expression (GO:0010628)regulation of cell migration (GO:0030334)response to oxidative stress (GO:0006979)response to xenobiotic stimulus (GO:0009410)signal transduction (GO:0007165)type 1 fibroblast growth factor receptor binding (GO:0005105)type 1 fibroblast growth factor receptor binding (GO:0005105)type 1 fibroblast growth factor receptor binding (GO:0005105)type 2 fibroblast growth factor receptor binding (GO:0005111)type 2 fibroblast growth factor receptor binding (GO:0005111)type 2 fibroblast growth factor receptor binding (GO:0005111)

Expression (TPM)

TFs regulating FGF8 0 TFs

Transcription factors with Perturb-seq knockdown data for FGF8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGF8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to FGF8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGF8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:101,282,747–101,283,297	497.3 kb	Distal (>10kb) Multiome HiCAR	74
chr10:101,285,534–101,286,046	494.5 kb	Distal (>10kb) Multiome HiCAR	150
chr10:101,288,327–101,289,007	491.7 kb	Distal (>10kb) Multiome HiCAR	96
chr10:101,569,467–101,571,017	210.1 kb	Distal (>10kb) Multiome HiCAR	558
chr10:101,587,742–101,588,624	192.1 kb	Distal (>10kb) Multiome HiCAR	673
chr10:101,602,717–101,603,282	177.4 kb	Distal (>10kb) Multiome HiCAR	348
chr10:101,606,618–101,607,814	173.1 kb	Distal (>10kb) Multiome HiCAR	143
chr10:101,667,996–101,669,307	111.7 kb	Distal (>10kb) Multiome	135
chr10:101,694,020–101,695,446	86.0 kb	Distal (>10kb) Multiome	821
chr10:101,749,494–101,750,047	30.6 kb	Distal (>10kb) Multiome	178
chr10:101,775,454–101,777,009	3.9 kb	Proximal (<10kb) Multiome	202
chr10:101,778,233–101,781,743	819 bp	At TSS Multiome	720
chr10:101,782,084–101,782,693	6.0 kb	Proximal (<10kb)	87
chr10:101,782,912–101,783,976	3.1 kb	Proximal (<10kb) Multiome	661
chr10:101,817,350–101,819,352	38.2 kb	Distal (>10kb) Multiome	1004
chr10:101,828,926–101,831,154	50.5 kb	Distal (>10kb) Multiome	697
chr10:101,840,663–101,841,471	60.7 kb	Distal (>10kb) Multiome	499
chr10:101,843,178–101,844,328	63.4 kb	Distal (>10kb) Multiome	277
chr10:101,893,696–101,895,001	114.1 kb	Distal (>10kb) Multiome	142
chr10:101,960,808–101,961,342	180.8 kb	Distal (>10kb) Multiome	47
chr10:102,055,474–102,056,435	275.7 kb	Distal (>10kb) Multiome	955
chr10:102,064,619–102,066,067	285.0 kb	Distal (>10kb) Multiome	778

Genome Browser

Genomic view of the FGF8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.