This 19-gene module includes JAK2, MGMT, SPINK5, PDGFD, and CRPPA, with enrichment in JAK signaling, growth factor activity, and kinase binding. Knockdown of SOX11, SMAD5, SOX4, CTBP1, and HNF1B activates this module, suggesting these transcriptional regulators normally suppress these genes during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.