The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for MYO5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:49,905,054–49,905,920 | 289.7 kb | Distal (>10kb) Multiome HiCAR | 75 | |
| chr18:49,911,085–49,912,315 | 283.5 kb | Distal (>10kb) Multiome HiCAR | 185 | |
| chr18:49,959,032–49,959,704 | 235.7 kb | Distal (>10kb) Multiome | 100 | |
| chr18:50,194,148–50,195,562 | 3 bp | At TSS Multiome | 482 | |
| chr18:50,203,797–50,204,272 | 8.6 kb | Proximal (<10kb) | 252 | |
| chr18:50,230,869–50,232,199 | 36.5 kb | Distal (>10kb) Multiome | 139 | |
| chr18:50,232,326–50,232,896 | 37.6 kb | Distal (>10kb) Multiome | 108 | |
| chr18:50,266,119–50,266,730 | 71.4 kb | Distal (>10kb) Multiome | 493 | |
| chr18:50,268,096–50,268,782 | 73.4 kb | Distal (>10kb) Multiome | 343 | |
| chr18:50,281,123–50,282,656 | 86.5 kb | Distal (>10kb) Multiome | 877 | |
| chr18:50,287,072–50,288,411 | 92.7 kb | Distal (>10kb) Multiome | 897 | |
| chr18:50,307,523–50,307,991 | 112.7 kb | Distal (>10kb) Multiome | 265 | |
| chr18:50,374,233–50,375,652 | 179.9 kb | Distal (>10kb) Multiome | 732 | |
| chr18:50,398,965–50,399,883 | 204.1 kb | Distal (>10kb) Multiome | 106 |
Genomic view of the MYO5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.