This gene encodes a cycling membrane protein which is an endoplasmic reticulum-golgi intermediate compartment (ERGIC) protein which interacts with other members of this protein family to increase their turnover. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ERGIC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERGIC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERGIC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:172,640,809–172,642,014 | 193.1 kb | Distal (>10kb) Multiome | 468 | |
| chr5:172,683,287–172,684,318 | 150.3 kb | Distal (>10kb) Multiome | 215 | |
| chr5:172,697,353–172,697,964 | 136.7 kb | Distal (>10kb) Multiome | 445 | |
| chr5:172,700,111–172,700,934 | 133.8 kb | Distal (>10kb) Multiome | 131 | |
| chr5:172,765,066–172,765,738 | 68.9 kb | Distal (>10kb) Multiome HiCAR | 748 | |
| chr5:172,769,970–172,772,642 | 63.1 kb | Distal (>10kb) Multiome HiCAR | 1190 | |
| chr5:172,828,888–172,829,516 | 5.0 kb | Proximal (<10kb) Multiome | 139 | |
| chr5:172,833,492–172,835,141 | 82 bp | At TSS Multiome | 673 | |
| chr5:172,941,457–172,942,000 | 107.4 kb | Distal (>10kb) Multiome | 22 | |
| chr5:172,958,380–172,959,872 | 125.0 kb | Distal (>10kb) Multiome | 868 | |
| chr5:172,983,384–172,984,597 | 149.4 kb | Distal (>10kb) Multiome | 848 | |
| chr5:173,055,699–173,057,854 | 223.0 kb | Distal (>10kb) Multiome | 1049 |
Genomic view of the ERGIC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.