This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FOXO3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXO3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXO3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:108,260,173–108,261,671 | 299.7 kb | Distal (>10kb) Multiome | 970 | |
| chr6:108,294,541–108,295,678 | 266.0 kb | Distal (>10kb) Multiome | 880 | |
| chr6:108,557,184–108,561,557 | 74 bp | At TSS Multiome | 1119 | |
| chr6:108,561,776–108,563,199 | 1.9 kb | Proximal (<10kb) Multiome | 782 | |
| chr6:108,781,208–108,782,610 | 220.6 kb | Distal (>10kb) Multiome HiCAR | 561 | |
| chr6:108,838,106–108,838,816 | 277.5 kb | Distal (>10kb) Multiome HiCAR | 212 | |
| chr6:108,847,848–108,848,955 | 287.5 kb | Distal (>10kb) Multiome HiCAR | 734 |
Genomic view of the FOXO3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.