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DE-4.16

Submodule 16 genes

Cytoplasmic scaffolding and aldehyde metabolism functions

This 16-gene module includes IQGAP1, ARRB1, ALDH3A2, and FLVCR1, with enrichment in cytoplasmic scaffolding, aldehyde metabolism, and protein transport pathways. Knockdown of SMARCC1 activates this module. Knockdown of ZNF431 represses this module.

Key terms: glomerular epithelium development glomerular epithelial cell differentiation negative adaptation of signaling pathway adaptation of signaling pathway Notable genes: IQGAP1 ARRB1 ALDH3A2 FLVCR1 BASP1 MKRN1 PPM1K PPP1R16B Top TFs: SMARCC1 ZNF431

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (16)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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