This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for PARD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:34,739,793–34,740,506 | 75.2 kb | Distal (>10kb) Multiome | 353 | |
| chr10:34,768,335–34,769,367 | 46.7 kb | Distal (>10kb) Multiome | 205 | |
| chr10:34,802,414–34,803,257 | 12.5 kb | Distal (>10kb) Multiome | 156 | |
| chr10:34,808,483–34,809,768 | 6.1 kb | Proximal (<10kb) Multiome | 231 | |
| chr10:34,813,705–34,816,058 | 143 bp | At TSS Multiome | 650 | |
| chr10:34,816,181–34,816,321 | 856 bp | At TSS | 126 | |
| chr10:34,816,472–34,816,868 | 1.1 kb | Proximal (<10kb) | 132 | |
| chr10:35,089,654–35,090,939 | 275.1 kb | Distal (>10kb) Multiome | 797 |
Genomic view of the PARD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.