This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBLIM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBLIM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBLIM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:15,523,864–15,525,570 | 233.3 kb | Distal (>10kb) Multiome | 674 | |
| chr1:15,526,118–15,527,442 | 231.1 kb | Distal (>10kb) Multiome | 899 | |
| chr1:15,584,405–15,585,197 | 173.2 kb | Distal (>10kb) Multiome | 693 | |
| chr1:15,603,163–15,603,936 | 154.3 kb | Distal (>10kb) Multiome | 795 | |
| chr1:15,616,785–15,618,260 | 140.6 kb | Distal (>10kb) Multiome | 909 | |
| chr1:15,676,618–15,677,408 | 80.8 kb | Distal (>10kb) Multiome | 95 | |
| chr1:15,741,258–15,741,859 | 16.4 kb | Distal (>10kb) Multiome | 436 | |
| chr1:15,757,615–15,759,609 | 640 bp | At TSS Multiome | 439 | |
| chr1:15,799,931–15,800,776 | 42.4 kb | Distal (>10kb) Multiome | 734 | |
| chr1:15,834,229–15,836,682 | 78.1 kb | Distal (>10kb) Multiome | 1154 | |
| chr1:15,847,036–15,848,900 | 89.7 kb | Distal (>10kb) Multiome | 817 | |
| chr1:15,849,314–15,850,241 | 91.7 kb | Distal (>10kb) Multiome | 788 | |
| chr1:15,975,319–15,976,269 | 217.9 kb | Distal (>10kb) Multiome | 788 | |
| chr1:16,012,632–16,013,679 | 255.2 kb | Distal (>10kb) Multiome | 615 | |
| chr1:16,026,326–16,027,360 | 268.9 kb | Distal (>10kb) Multiome | 186 | |
| chr1:16,032,851–16,033,317 | 275.1 kb | Distal (>10kb) Multiome | 349 | |
| chr1:16,048,527–16,049,209 | 290.8 kb | Distal (>10kb) Multiome | 288 |
Genomic view of the FBLIM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.