The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Transcription factors with Perturb-seq knockdown data for CDC42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:21,782,310–21,784,177 | 269.3 kb | Distal (>10kb) Multiome | 1096 | |
| chr1:21,814,299–21,814,932 | 238.1 kb | Distal (>10kb) Multiome | 227 | |
| chr1:21,922,465–21,923,180 | 129.9 kb | Distal (>10kb) Multiome | 263 | |
| chr1:21,936,519–21,938,007 | 115.2 kb | Distal (>10kb) Multiome | 630 | |
| chr1:22,024,858–22,026,137 | 27.2 kb | Distal (>10kb) Multiome | 937 | |
| chr1:22,052,314–22,053,858 | 4 bp | At TSS Multiome | 912 | |
| chr1:22,142,284–22,143,888 | 90.7 kb | Distal (>10kb) Multiome | 298 | |
| chr1:22,154,320–22,155,232 | 102.2 kb | Distal (>10kb) Multiome | 103 |
Genomic view of the CDC42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.