This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for GATA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GATA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GATA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:21,912,423–21,913,408 | 256.7 kb | Distal (>10kb) Multiome HiCAR | 73 | |
| chr18:21,933,673–21,935,412 | 234.9 kb | Distal (>10kb) Multiome HiCAR | 335 | |
| chr18:21,990,759–21,991,669 | 178.3 kb | Distal (>10kb) Multiome HiCAR | 354 | |
| chr18:22,020,051–22,020,863 | 149.1 kb | Distal (>10kb) Multiome HiCAR | 228 | |
| chr18:22,026,039–22,027,477 | 142.6 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr18:22,079,674–22,080,842 | 89.5 kb | Distal (>10kb) Multiome | 105 | |
| chr18:22,093,896–22,094,823 | 75.2 kb | Distal (>10kb) Multiome | 197 | |
| chr18:22,101,589–22,102,358 | 67.6 kb | Distal (>10kb) Multiome | 40 | |
| chr18:22,110,470–22,110,946 | 58.9 kb | Distal (>10kb) Multiome | 169 | |
| chr18:22,158,498–22,160,201 | 10.3 kb | Distal (>10kb) Multiome | 129 | |
| chr18:22,161,645–22,162,076 | 7.5 kb | Proximal (<10kb) | 17 | |
| chr18:22,165,323–22,166,006 | 3.6 kb | Proximal (<10kb) | 73 | |
| chr18:22,167,956–22,172,162 | 320 bp | At TSS Multiome | 792 | |
| chr18:22,176,799–22,177,309 | 7.2 kb | Proximal (<10kb) | 146 | |
| chr18:22,178,046–22,178,875 | 8.5 kb | Proximal (<10kb) | 275 | |
| chr18:22,324,187–22,324,960 | 154.9 kb | Distal (>10kb) Multiome | 176 |
Genomic view of the GATA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.