This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FLII. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLII upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLII, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:17,971,984–17,973,164 | 286.1 kb | Distal (>10kb) Multiome | 716 | |
| chr17:18,035,659–18,036,594 | 222.7 kb | Distal (>10kb) Multiome | 186 | |
| chr17:18,038,656–18,040,279 | 219.4 kb | Distal (>10kb) Multiome | 839 | |
| chr17:18,153,365–18,154,352 | 104.8 kb | Distal (>10kb) Multiome | 244 | |
| chr17:18,157,790–18,158,725 | 100.5 kb | Distal (>10kb) Multiome | 292 | |
| chr17:18,182,585–18,185,065 | 75.2 kb | Distal (>10kb) Multiome | 1051 | |
| chr17:18,224,148–18,226,173 | 34.0 kb | Distal (>10kb) Multiome | 680 | |
| chr17:18,246,777–18,247,912 | 11.4 kb | Distal (>10kb) Multiome | 314 | |
| chr17:18,257,865–18,259,083 | 61 bp | At TSS Multiome | 684 | |
| chr17:18,260,145–18,261,582 | 1.9 kb | Proximal (<10kb) Multiome | 778 | |
| chr17:18,268,361–18,268,595 | 9.6 kb | Proximal (<10kb) | 55 | |
| chr17:18,314,513–18,315,715 | 56.4 kb | Distal (>10kb) Multiome | 865 | |
| chr17:18,363,090–18,363,830 | 104.8 kb | Distal (>10kb) Multiome | 760 |
Genomic view of the FLII locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.