HGS
hepatocyte growth factor-regulated tyrosine kinase substrate | Hrs, Vps27, ZFYVE8

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

Member of: DE-4 DE-4.20
Biological processes 43 terms
ESCRT-0 complex (GO:0033565)ESCRT-0 complex (GO:0033565)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)early endosome (GO:0005769)early endosome (GO:0005769)early endosome membrane (GO:0031901)endocytic recycling (GO:0032456)endosomal transport (GO:0016197)endosome (GO:0005768)extracellular exosome (GO:0070062)identical protein binding (GO:0042802)macroautophagy (GO:0016236)macroautophagy (GO:0016236)membrane fission (GO:0090148)membrane invagination (GO:0010324)metal ion binding (GO:0046872)multivesicular body assembly (GO:0036258)multivesicular body assembly (GO:0036258)multivesicular body membrane (GO:0032585)negative regulation of angiogenesis (GO:0016525)negative regulation of cell population proliferation (GO:0008285)negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)negative regulation of receptor signaling pathway via JAK-STAT (GO:0046426)negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)phagocytic vesicle lumen (GO:0097013)phosphatidylinositol binding (GO:0035091)positive regulation of exosomal secretion (GO:1903543)positive regulation of gene expression (GO:0010628)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein localization to membrane (GO:0072657)protein targeting to lysosome (GO:0006622)protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043328)receptor internalization (GO:0031623)regulation of MAP kinase activity (GO:0043405)regulation of protein catabolic process (GO:0042176)signal transduction (GO:0007165)ubiquitin binding (GO:0043130)ubiquitin binding (GO:0043130)ubiquitin-like protein ligase binding (GO:0044389)ubiquitin-modified protein reader activity (GO:0140036)
Expression (TPM)
HGS — as a Regulated Gene

TFs regulating HGS 0 TFs

Transcription factors with Perturb-seq knockdown data for HGS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HGS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to HGS

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HGS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:81,393,141–81,395,575 289.9 kb Distal (>10kb) Multiome 1168
chr17:81,396,480–81,397,832 286.6 kb Distal (>10kb) Multiome 646
chr17:81,481,258–81,481,865 202.4 kb Distal (>10kb) Multiome 348
chr17:81,483,927–81,484,829 199.5 kb Distal (>10kb) Multiome 828
chr17:81,487,690–81,488,371 196.0 kb Distal (>10kb) Multiome 721
chr17:81,511,887–81,515,656 171.1 kb Distal (>10kb) Multiome 1116
chr17:81,518,632–81,519,878 164.5 kb Distal (>10kb) Multiome 617
chr17:81,537,462–81,537,907 146.3 kb Distal (>10kb) Multiome 282
chr17:81,551,821–81,553,314 130.8 kb Distal (>10kb) Multiome 845
chr17:81,636,404–81,637,301 47.0 kb Distal (>10kb) Multiome 946
chr17:81,648,048–81,648,550 35.7 kb Distal (>10kb) Multiome 88
chr17:81,652,970–81,653,572 30.8 kb Distal (>10kb) Multiome 188
chr17:81,666,251–81,667,166 17.3 kb Distal (>10kb) Multiome 901
chr17:81,683,344–81,684,556 87 bp At TSS Multiome 926
chr17:81,702,879–81,703,868 19.4 kb Distal (>10kb) Multiome 981
chr17:81,711,721–81,712,812 28.3 kb Distal (>10kb) Multiome 1056
chr17:81,832,473–81,833,976 149.3 kb Distal (>10kb) Multiome 1015
chr17:81,859,762–81,861,595 176.9 kb Distal (>10kb) Multiome 1134
chr17:81,868,421–81,868,978 184.6 kb Distal (>10kb) Multiome 577
chr17:81,869,000–81,872,289 187.3 kb Distal (>10kb) Multiome 1136
chr17:81,891,143–81,892,257 207.8 kb Distal (>10kb) Multiome 969
chr17:81,910,443–81,911,980 227.6 kb Distal (>10kb) Multiome 806
chr17:81,917,586–81,918,522 234.2 kb Distal (>10kb) Multiome 619
chr17:81,923,285–81,923,863 239.5 kb Distal (>10kb) Multiome 399
chr17:81,926,141–81,929,133 243.9 kb Distal (>10kb) Multiome 1034
chr17:81,936,855–81,937,682 253.4 kb Distal (>10kb) Multiome 854
chr17:81,959,299–81,962,169 275.8 kb Distal (>10kb) Multiome 805
chr17:81,966,804–81,968,359 284.1 kb Distal (>10kb) Multiome 908
chr17:81,976,595–81,978,312 293.7 kb Distal (>10kb) Multiome 1001

Genome Browser

Genomic view of the HGS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:81,383,141 – 81,988,312
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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