This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for FLVCR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLVCR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLVCR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:212,558,067–212,559,384 | 299.3 kb | Distal (>10kb) Multiome | 891 | |
| chr1:212,605,830–212,610,097 | 248.6 kb | Distal (>10kb) Multiome | 1097 | |
| chr1:212,629,910–212,630,849 | 228.0 kb | Distal (>10kb) Multiome | 331 | |
| chr1:212,665,118–212,665,789 | 192.8 kb | Distal (>10kb) Multiome | 678 | |
| chr1:212,698,874–212,700,500 | 158.9 kb | Distal (>10kb) Multiome | 710 | |
| chr1:212,791,461–212,792,424 | 66.4 kb | Distal (>10kb) Multiome HiCAR | 1108 | |
| chr1:212,852,157–212,852,462 | 5.8 kb | Proximal (<10kb) | 52 | |
| chr1:212,857,574–212,859,115 | 152 bp | At TSS Multiome | 946 | |
| chr1:212,860,361–212,860,512 | 2.1 kb | Proximal (<10kb) | 44 | |
| chr1:212,860,779–212,861,295 | 2.7 kb | Proximal (<10kb) Multiome | 315 | |
| chr1:212,907,964–212,908,918 | 50.1 kb | Distal (>10kb) Multiome | 62 | |
| chr1:212,909,569–212,910,174 | 51.8 kb | Distal (>10kb) Multiome | 97 | |
| chr1:212,916,378–212,917,359 | 58.7 kb | Distal (>10kb) Multiome | 306 | |
| chr1:212,928,624–212,929,308 | 70.8 kb | Distal (>10kb) Multiome | 145 | |
| chr1:212,950,130–212,951,519 | 92.2 kb | Distal (>10kb) Multiome | 457 | |
| chr1:212,967,458–212,968,096 | 109.6 kb | Distal (>10kb) Multiome | 178 | |
| chr1:213,015,122–213,015,983 | 157.4 kb | Distal (>10kb) Multiome | 888 | |
| chr1:213,050,888–213,051,797 | 193.0 kb | Distal (>10kb) Multiome | 880 | |
| chr1:213,066,260–213,067,034 | 208.4 kb | Distal (>10kb) Multiome | 70 |
Genomic view of the FLVCR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.