This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for JUP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JUP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JUP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:41,527,111–41,529,407 | 258.3 kb | Distal (>10kb) Multiome | 635 | |
| chr17:41,529,883–41,531,145 | 256.2 kb | Distal (>10kb) Multiome | 504 | |
| chr17:41,548,740–41,549,518 | 237.6 kb | Distal (>10kb) Multiome | 698 | |
| chr17:41,579,549–41,580,064 | 207.0 kb | Distal (>10kb) Multiome | 335 | |
| chr17:41,647,765–41,648,495 | 138.6 kb | Distal (>10kb) Multiome | 519 | |
| chr17:41,662,549–41,663,015 | 123.8 kb | Distal (>10kb) Multiome | 643 | |
| chr17:41,665,564–41,667,291 | 119.5 kb | Distal (>10kb) Multiome | 883 | |
| chr17:41,688,103–41,690,064 | 97.9 kb | Distal (>10kb) Multiome | 1236 | |
| chr17:41,733,761–41,735,187 | 52.0 kb | Distal (>10kb) Multiome | 577 | |
| chr17:41,738,054–41,738,690 | 48.5 kb | Distal (>10kb) Multiome | 596 | |
| chr17:41,784,215–41,784,875 | 1.2 kb | Proximal (<10kb) | 323 | |
| chr17:41,784,980–41,787,229 | 134 bp | At TSS Multiome | 958 | |
| chr17:41,793,046–41,793,415 | 7.0 kb | Proximal (<10kb) | 561 | |
| chr17:41,793,527–41,794,326 | 7.2 kb | Proximal (<10kb) Multiome | 597 | |
| chr17:41,800,647–41,802,040 | 15.2 kb | Distal (>10kb) Multiome | 766 | |
| chr17:41,811,252–41,813,275 | 26.2 kb | Distal (>10kb) Multiome | 997 | |
| chr17:41,835,756–41,836,400 | 49.5 kb | Distal (>10kb) Multiome | 568 | |
| chr17:41,864,608–41,865,695 | 78.7 kb | Distal (>10kb) Multiome | 913 | |
| chr17:41,913,670–41,914,569 | 127.4 kb | Distal (>10kb) Multiome | 190 | |
| chr17:41,918,026–41,919,794 | 132.5 kb | Distal (>10kb) Multiome | 956 | |
| chr17:41,930,220–41,930,908 | 143.8 kb | Distal (>10kb) Multiome | 915 | |
| chr17:41,965,771–41,967,327 | 180.1 kb | Distal (>10kb) Multiome | 920 | |
| chr17:42,016,953–42,018,102 | 230.8 kb | Distal (>10kb) Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 233.3 kb | Distal (>10kb) Multiome | 791 | |
| chr17:42,050,326–42,051,046 | 263.9 kb | Distal (>10kb) Multiome | 514 |
Genomic view of the JUP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.