HSPB1

heat shock protein family B (small) member 1 | CMT2F, HSP27, HSP28, Hs.76067, Hsp25

This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

Member of: DE-4 DE-4.1 Developmental clusters: GC6

Biological processes 69 terms

RNA binding (GO:0003723)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)Z disc (GO:0030018)anterograde axonal protein transport (GO:0099641)axon cytoplasm (GO:1904115)cellular response to vascular endothelial growth factor stimulus (GO:0035924)contractile muscle fiber (GO:0043292)cornified envelope (GO:0001533)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)extracellular region (GO:0005576)focal adhesion (GO:0005925)identical protein binding (GO:0042802)identical protein binding (GO:0042802)intestinal epithelial structure maintenance (GO:0060729)intracellular signal transduction (GO:0035556)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)negative regulation of protein kinase C signaling (GO:0090038)negative regulation of protein kinase C signaling (GO:0090038)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)platelet aggregation (GO:0070527)positive regulation of angiogenesis (GO:0045766)positive regulation of blood vessel endothelial cell migration (GO:0043536)positive regulation of endothelial cell chemotaxis (GO:2001028)positive regulation of interleukin-1 beta production (GO:0032731)positive regulation of interleukin-1 beta production (GO:0032731)positive regulation of tumor necrosis factor production (GO:0032760)positive regulation of tumor necrosis factor production (GO:0032760)proteasome complex (GO:0000502)protein binding (GO:0005515)protein folding (GO:0006457)protein folding chaperone (GO:0044183)protein folding chaperone (GO:0044183)protein homodimerization activity (GO:0042803)protein kinase C binding (GO:0005080)protein kinase C binding (GO:0005080)protein kinase C inhibitor activity (GO:0008426)protein kinase C inhibitor activity (GO:0008426)protein kinase binding (GO:0019901)protein refolding (GO:0042026)protein stabilization (GO:0050821)regulation of autophagy (GO:0010506)regulation of canonical NF-kappaB signal transduction (GO:0043122)regulation of canonical NF-kappaB signal transduction (GO:0043122)regulation of protein phosphorylation (GO:0001932)regulation of translational initiation (GO:0006446)response to heat (GO:0009408)response to unfolded protein (GO:0006986)response to unfolded protein (GO:0006986)response to virus (GO:0009615)spindle (GO:0005819)ubiquitin binding (GO:0043130)unfolded protein binding (GO:0051082)vascular endothelial growth factor receptor signaling pathway (GO:0048010)

Expression (TPM)

TFs regulating HSPB1 0 TFs

Transcription factors with Perturb-seq knockdown data for HSPB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HSPB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:76,047,582–76,048,952	254.6 kb	Distal (>10kb) Multiome	920
chr7:76,073,173–76,073,663	229.2 kb	Distal (>10kb) Multiome	100
chr7:76,163,449–76,164,544	138.7 kb	Distal (>10kb) Multiome	132
chr7:76,166,338–76,167,166	136.0 kb	Distal (>10kb) Multiome	644
chr7:76,177,965–76,178,641	124.4 kb	Distal (>10kb) Multiome	670
chr7:76,201,356–76,202,307	100.9 kb	Distal (>10kb) Multiome	937
chr7:76,234,695–76,235,681	67.4 kb	Distal (>10kb) Multiome	329
chr7:76,259,707–76,261,052	42.3 kb	Distal (>10kb) Multiome	332
chr7:76,267,044–76,267,853	35.3 kb	Distal (>10kb) Multiome	211
chr7:76,282,299–76,283,220	20.0 kb	Distal (>10kb) Multiome	237
chr7:76,291,428–76,292,275	10.8 kb	Distal (>10kb) Multiome HiCAR	767
chr7:76,294,736–76,295,157	7.5 kb	Proximal (<10kb)	492
chr7:76,302,207–76,304,173	154 bp	At TSS Multiome	943
chr7:76,314,028–76,314,686	11.7 kb	Distal (>10kb) Multiome	715
chr7:76,317,523–76,319,173	15.5 kb	Distal (>10kb) Multiome	840
chr7:76,358,237–76,359,989	56.6 kb	Distal (>10kb) Multiome	1036
chr7:76,379,650–76,380,602	77.4 kb	Distal (>10kb) Multiome	853
chr7:76,392,882–76,394,121	90.6 kb	Distal (>10kb) Multiome	932
chr7:76,395,928–76,396,741	93.5 kb	Distal (>10kb) Multiome	152
chr7:76,397,187–76,397,970	94.9 kb	Distal (>10kb) Multiome	496
chr7:76,409,261–76,409,956	107.1 kb	Distal (>10kb) Multiome	281
chr7:76,510,075–76,510,721	207.7 kb	Distal (>10kb) Multiome	201
chr7:76,548,975–76,549,826	246.6 kb	Distal (>10kb) Multiome	505

Genome Browser

Genomic view of the HSPB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.