This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for FLNB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FLNB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FLNB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:57,727,873–57,728,338 | 280.3 kb | Distal (>10kb) Multiome | 20 | |
| chr3:57,755,657–57,757,330 | 252.2 kb | Distal (>10kb) Multiome | 930 | |
| chr3:57,969,842–57,970,308 | 38.4 kb | Distal (>10kb) Multiome | 332 | |
| chr3:57,992,220–57,993,259 | 15.7 kb | Distal (>10kb) Multiome | 382 | |
| chr3:57,998,619–57,999,287 | 9.6 kb | Proximal (<10kb) Multiome | 336 | |
| chr3:58,002,992–58,003,441 | 5.2 kb | Proximal (<10kb) Multiome | 128 | |
| chr3:58,006,378–58,007,041 | 1.7 kb | Proximal (<10kb) Multiome | 155 | |
| chr3:58,007,913–58,009,633 | 75 bp | At TSS Multiome | 747 | |
| chr3:58,010,232–58,010,464 | 1.8 kb | Proximal (<10kb) | 180 | |
| chr3:58,021,094–58,022,164 | 13.1 kb | Distal (>10kb) Multiome | 478 | |
| chr3:58,034,682–58,035,269 | 26.6 kb | Distal (>10kb) Multiome | 260 | |
| chr3:58,049,229–58,049,752 | 41.0 kb | Distal (>10kb) Multiome | 668 | |
| chr3:58,177,450–58,178,460 | 169.5 kb | Distal (>10kb) Multiome | 551 | |
| chr3:58,187,606–58,188,058 | 179.5 kb | Distal (>10kb) Multiome | 377 | |
| chr3:58,217,189–58,217,783 | 209.0 kb | Distal (>10kb) Multiome | 545 | |
| chr3:58,222,267–58,222,780 | 214.1 kb | Distal (>10kb) Multiome | 115 | |
| chr3:58,236,918–58,238,686 | 229.2 kb | Distal (>10kb) Multiome | 727 | |
| chr3:58,305,855–58,306,746 | 297.9 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the FLNB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.