Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FZD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FZD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FZD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:201,780,355–201,781,686 | 252.9 kb | Distal (>10kb) Multiome | 963 | |
| chr2:201,787,334–201,788,076 | 246.2 kb | Distal (>10kb) Multiome | 227 | |
| chr2:201,858,878–201,859,345 | 174.8 kb | Distal (>10kb) Multiome HiCAR | 246 | |
| chr2:201,860,619–201,861,352 | 172.9 kb | Distal (>10kb) Multiome HiCAR | 253 | |
| chr2:201,866,586–201,867,010 | 167.0 kb | Distal (>10kb) Multiome HiCAR | 139 | |
| chr2:201,906,909–201,907,931 | 126.5 kb | Distal (>10kb) Multiome HiCAR | 255 | |
| chr2:201,929,476–201,930,044 | 104.0 kb | Distal (>10kb) Multiome HiCAR | 78 | |
| chr2:201,932,304–201,933,049 | 101.2 kb | Distal (>10kb) Multiome | 131 | |
| chr2:201,948,994–201,950,276 | 84.3 kb | Distal (>10kb) Multiome HiCAR | 334 | |
| chr2:201,972,639–201,973,266 | 60.9 kb | Distal (>10kb) Multiome | 195 | |
| chr2:202,019,731–202,020,536 | 13.7 kb | Distal (>10kb) Multiome | 118 | |
| chr2:202,023,052–202,024,286 | 10.3 kb | Distal (>10kb) Multiome | 272 | |
| chr2:202,031,990–202,032,196 | 1.7 kb | Proximal (<10kb) | 87 | |
| chr2:202,032,848–202,036,232 | 121 bp | At TSS Multiome | 769 | |
| chr2:202,038,976–202,040,047 | 5.9 kb | Proximal (<10kb) Multiome | 233 | |
| chr2:202,148,653–202,149,792 | 115.5 kb | Distal (>10kb) Multiome | 213 | |
| chr2:202,163,899–202,164,942 | 130.7 kb | Distal (>10kb) Multiome HiCAR | 79 | |
| chr2:202,237,794–202,239,082 | 204.7 kb | Distal (>10kb) Multiome | 820 | |
| chr2:202,249,669–202,250,510 | 216.3 kb | Distal (>10kb) Multiome | 213 | |
| chr2:202,265,167–202,266,195 | 231.8 kb | Distal (>10kb) Multiome | 931 |
Genomic view of the FZD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.