This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for WNK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WNK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WNK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:459,530–460,568 | 292.7 kb | Distal (>10kb) Multiome | 338 | |
| chr12:509,461–510,940 | 242.1 kb | Distal (>10kb) Multiome | 399 | |
| chr12:569,602–571,188 | 182.7 kb | Distal (>10kb) Multiome HiCAR | 800 | |
| chr12:642,622–643,509 | 109.6 kb | Distal (>10kb) Multiome | 556 | |
| chr12:669,635–670,134 | 82.7 kb | Distal (>10kb) Multiome | 33 | |
| chr12:740,453–741,486 | 11.6 kb | Distal (>10kb) Multiome | 114 | |
| chr12:751,121–751,920 | 1.3 kb | Proximal (<10kb) Multiome | 860 | |
| chr12:752,026–753,528 | 58 bp | At TSS Multiome | 747 | |
| chr12:753,697–754,164 | 1.1 kb | Proximal (<10kb) | 358 | |
| chr12:903,972–904,535 | 7.3 kb | Proximal (<10kb) | 107 | |
| chr12:905,407–906,187 | 8.8 kb | Proximal (<10kb) | 85 | |
| chr12:949,091–950,483 | 197.2 kb | Distal (>10kb) Multiome | 982 | |
| chr12:990,383–991,780 | 238.6 kb | Distal (>10kb) Multiome | 990 | |
| chr12:1,580,606–1,581,311 | 828.2 kb | Distal (>10kb) Multiome HiCAR | 62 |
Genomic view of the WNK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.