This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for CRPPA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRPPA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRPPA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:16,418,530–16,418,810 | 2.7 kb | Proximal (<10kb) | 17 | |
| chr7:16,420,192–16,422,117 | 521 bp | At TSS Multiome | 1014 | |
| chr7:16,511,401–16,512,647 | 90.7 kb | Distal (>10kb) Multiome | 110 | |
| chr7:16,587,596–16,588,471 | 166.4 kb | Distal (>10kb) Multiome HiCAR | 148 | |
| chr7:16,644,616–16,647,076 | 224.4 kb | Distal (>10kb) Multiome | 1028 |
Genomic view of the CRPPA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.