OGA

O-GlcNAcase | MEA5, NCOAT, MGEA5

The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

Member of: DE-4 DE-4.22

Biological processes 19 terms

N-acetylglucosamine metabolic process (GO:0006044)N-acetylglucosamine metabolic process (GO:0006044)[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity (GO:0102571)[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity (GO:0102571)[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity (GO:0102571)catalytic activity, acting on a protein (GO:0140096)cytoplasm (GO:0005737)cytosol (GO:0005829)glycoprotein catabolic process (GO:0006516)glycoprotein metabolic process (GO:0009100)hexosaminidase activity (GO:0015929)hexosaminidase activity (GO:0015929)hyalurononglucosaminidase activity (GO:0004415)identical protein binding (GO:0042802)membrane (GO:0016020)nucleus (GO:0005634)nucleus (GO:0005634)protein O-linked glycosylation (GO:0006493)protein deglycosylation (GO:0006517)

Expression (TPM)

TFs regulating OGA 0 TFs

Transcription factors with Perturb-seq knockdown data for OGA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OGA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to OGA

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OGA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:101,569,467–101,571,017	248.2 kb	Distal (>10kb) Multiome	558
chr10:101,587,742–101,588,624	230.2 kb	Distal (>10kb) Multiome	673
chr10:101,602,717–101,603,282	215.5 kb	Distal (>10kb) Multiome	348
chr10:101,606,618–101,607,814	211.2 kb	Distal (>10kb) Multiome	143
chr10:101,667,996–101,669,307	149.8 kb	Distal (>10kb) Multiome	135
chr10:101,694,020–101,695,446	124.1 kb	Distal (>10kb) Multiome	821
chr10:101,749,494–101,750,047	68.7 kb	Distal (>10kb) Multiome	178
chr10:101,775,454–101,777,009	42.0 kb	Distal (>10kb) Multiome	202
chr10:101,778,233–101,781,743	37.3 kb	Distal (>10kb) Multiome	720
chr10:101,782,912–101,783,976	35.0 kb	Distal (>10kb) Multiome	661
chr10:101,817,350–101,819,352	134 bp	At TSS Multiome	1004
chr10:101,828,926–101,831,154	12.4 kb	Distal (>10kb) Multiome	697
chr10:101,839,408–101,839,998	21.2 kb	Distal (>10kb) Multiome	196
chr10:101,840,663–101,841,471	22.6 kb	Distal (>10kb) Multiome	499
chr10:101,843,178–101,844,328	25.3 kb	Distal (>10kb) Multiome	277
chr10:101,893,696–101,895,001	76.1 kb	Distal (>10kb) Multiome	142
chr10:101,960,808–101,961,342	142.7 kb	Distal (>10kb) Multiome	47
chr10:102,055,474–102,056,435	237.7 kb	Distal (>10kb) Multiome	955
chr10:102,064,619–102,066,067	246.9 kb	Distal (>10kb) Multiome	778
chr10:102,114,483–102,115,579	296.6 kb	Distal (>10kb) Multiome	546

Genome Browser

Genomic view of the OGA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.