This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for CTNND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTNND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTNND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,480,236–57,481,014 | 281.3 kb | Distal (>10kb) Multiome | 300 | |
| chr11:57,482,336–57,483,518 | 278.7 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 268.2 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 262.1 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 247.4 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 230.9 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 193.7 kb | Distal (>10kb) Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 163.7 kb | Distal (>10kb) Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 123.7 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,644,541–57,645,304 | 116.9 kb | Distal (>10kb) Multiome | 237 | |
| chr11:57,646,682–57,652,802 | 111.9 kb | Distal (>10kb) Multiome | 580 | |
| chr11:57,656,843–57,658,231 | 104.2 kb | Distal (>10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 94.0 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 49.6 kb | Distal (>10kb) Multiome | 857 | |
| chr11:57,740,872–57,742,140 | 20.4 kb | Distal (>10kb) Multiome | 973 | |
| chr11:57,751,556–57,752,311 | 9.5 kb | Proximal (<10kb) | 181 | |
| chr11:57,761,276–57,762,144 | 81 bp | At TSS Multiome | 612 | |
| chr11:57,762,528–57,762,938 | 697 bp | At TSS | 153 | |
| chr11:57,763,675–57,763,870 | 1.8 kb | Proximal (<10kb) | 137 | |
| chr11:57,764,719–57,765,010 | 2.9 kb | Proximal (<10kb) | 89 | |
| chr11:57,765,120–57,765,344 | 3.3 kb | Proximal (<10kb) | 94 | |
| chr11:57,778,066–57,779,000 | 16.9 kb | Distal (>10kb) Multiome | 688 | |
| chr11:57,780,962–57,781,951 | 19.8 kb | Distal (>10kb) Multiome | 317 | |
| chr11:57,800,273–57,801,159 | 38.9 kb | Distal (>10kb) Multiome | 547 | |
| chr11:57,902,618–57,904,039 | 141.5 kb | Distal (>10kb) Multiome | 362 |
Genomic view of the CTNND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.