The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CCNG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:162,067,189–162,069,001 | 1369.0 kb | Distal (>10kb) Multiome HiCAR | 348 | |
| chr5:162,274,142–162,276,042 | 1161.8 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr5:162,279,851–162,281,314 | 1156.7 kb | Distal (>10kb) Multiome HiCAR | 87 | |
| chr5:163,273,656–163,274,943 | 163.3 kb | Distal (>10kb) Multiome | 149 | |
| chr5:163,330,258–163,331,560 | 106.6 kb | Distal (>10kb) Multiome | 240 | |
| chr5:163,334,244–163,334,828 | 103.1 kb | Distal (>10kb) Multiome | 66 | |
| chr5:163,340,037–163,340,700 | 97.2 kb | Distal (>10kb) Multiome | 37 | |
| chr5:163,432,842–163,434,227 | 4.1 kb | Proximal (<10kb) Multiome | 173 | |
| chr5:163,436,410–163,436,897 | 696 bp | At TSS | 63 | |
| chr5:163,437,029–163,438,386 | 29 bp | At TSS Multiome | 946 | |
| chr5:163,451,612–163,452,027 | 7.8 kb | Proximal (<10kb) | 12 | |
| chr5:163,459,472–163,462,155 | 22.8 kb | Distal (>10kb) Multiome | 1131 | |
| chr5:163,502,571–163,503,862 | 65.6 kb | Distal (>10kb) Multiome | 479 | |
| chr5:163,505,139–163,506,032 | 68.0 kb | Distal (>10kb) Multiome | 889 | |
| chr5:163,531,300–163,534,247 | 93.9 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the CCNG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.