This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018]
Transcription factors with Perturb-seq knockdown data for COLEC12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COLEC12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COLEC12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:267,462–268,836 | 232.7 kb | Distal (>10kb) Multiome | 1007 | |
| chr18:313,811–314,749 | 186.6 kb | Distal (>10kb) Multiome | 63 | |
| chr18:497,085–497,442 | 3.3 kb | Proximal (<10kb) | 159 | |
| chr18:499,464–499,730 | 991 bp | At TSS | 381 | |
| chr18:499,984–501,449 | 1 bp | At TSS Multiome | 306 | |
| chr18:516,064–516,762 | 15.6 kb | Distal (>10kb) Multiome | 96 | |
| chr18:596,942–597,511 | 96.3 kb | Distal (>10kb) Multiome | 522 | |
| chr18:657,152–658,975 | 157.7 kb | Distal (>10kb) Multiome | 968 | |
| chr18:685,991–687,114 | 185.8 kb | Distal (>10kb) Multiome | 127 | |
| chr18:712,215–713,458 | 212.0 kb | Distal (>10kb) Multiome | 797 |
Genomic view of the COLEC12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.