Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
Transcription factors with Perturb-seq knockdown data for PLIN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLIN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLIN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,581,475–4,581,916 | 285.9 kb | Distal (>10kb) Multiome | 358 | |
| chr19:4,597,380–4,598,540 | 269.5 kb | Distal (>10kb) Multiome | 280 | |
| chr19:4,633,303–4,633,826 | 234.2 kb | Distal (>10kb) Multiome | 500 | |
| chr19:4,636,101–4,636,717 | 231.3 kb | Distal (>10kb) Multiome | 445 | |
| chr19:4,639,001–4,640,103 | 228.3 kb | Distal (>10kb) Multiome | 710 | |
| chr19:4,669,686–4,671,221 | 197.3 kb | Distal (>10kb) Multiome | 797 | |
| chr19:4,678,652–4,679,681 | 188.5 kb | Distal (>10kb) Multiome | 164 | |
| chr19:4,723,373–4,724,832 | 143.7 kb | Distal (>10kb) Multiome | 1021 | |
| chr19:4,791,166–4,792,360 | 76.2 kb | Distal (>10kb) Multiome | 897 | |
| chr19:4,866,988–4,867,147 | 519 bp | At TSS | 293 | |
| chr19:4,867,260–4,868,220 | 105 bp | At TSS Multiome | 718 | |
| chr19:4,872,669–4,872,872 | 5.0 kb | Proximal (<10kb) | 300 | |
| chr19:4,908,827–4,910,489 | 42.3 kb | Distal (>10kb) Multiome | 766 | |
| chr19:4,968,227–4,969,595 | 101.2 kb | Distal (>10kb) Multiome | 764 | |
| chr19:5,048,124–5,048,589 | 180.7 kb | Distal (>10kb) Multiome | 444 |
Genomic view of the PLIN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.