Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for PPP3CC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP3CC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP3CC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:22,140,995–22,142,545 | 299.2 kb | Distal (>10kb) Multiome | 753 | |
| chr8:22,156,517–22,157,091 | 284.2 kb | Distal (>10kb) Multiome | 215 | |
| chr8:22,164,354–22,165,830 | 276.1 kb | Distal (>10kb) Multiome | 672 | |
| chr8:22,176,636–22,177,193 | 264.1 kb | Distal (>10kb) Multiome | 91 | |
| chr8:22,188,487–22,189,031 | 252.2 kb | Distal (>10kb) Multiome | 334 | |
| chr8:22,244,388–22,245,751 | 195.9 kb | Distal (>10kb) Multiome | 1013 | |
| chr8:22,275,120–22,276,011 | 165.7 kb | Distal (>10kb) Multiome | 195 | |
| chr8:22,365,087–22,366,071 | 75.5 kb | Distal (>10kb) Multiome | 444 | |
| chr8:22,366,837–22,368,383 | 73.8 kb | Distal (>10kb) Multiome | 859 | |
| chr8:22,440,466–22,441,769 | 15 bp | At TSS Multiome | 784 | |
| chr8:22,548,856–22,550,046 | 108.5 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr8:22,551,208–22,552,929 | 110.5 kb | Distal (>10kb) Multiome HiCAR | 406 | |
| chr8:22,561,173–22,562,479 | 120.8 kb | Distal (>10kb) Multiome HiCAR | 678 | |
| chr8:22,565,061–22,566,429 | 124.7 kb | Distal (>10kb) Multiome HiCAR | 404 | |
| chr8:22,574,221–22,574,708 | 133.4 kb | Distal (>10kb) Multiome | 527 | |
| chr8:22,578,724–22,579,696 | 138.1 kb | Distal (>10kb) Multiome | 404 | |
| chr8:22,588,723–22,589,902 | 148.2 kb | Distal (>10kb) Multiome HiCAR | 612 | |
| chr8:22,594,681–22,595,713 | 154.2 kb | Distal (>10kb) Multiome | 402 | |
| chr8:22,597,003–22,600,290 | 156.4 kb | Distal (>10kb) Multiome | 889 | |
| chr8:22,604,300–22,605,436 | 163.7 kb | Distal (>10kb) Multiome | 1053 | |
| chr8:22,622,764–22,623,329 | 182.0 kb | Distal (>10kb) Multiome | 431 | |
| chr8:22,658,639–22,659,248 | 217.8 kb | Distal (>10kb) Multiome | 290 | |
| chr8:22,668,686–22,669,459 | 228.0 kb | Distal (>10kb) Multiome | 637 | |
| chr8:22,691,357–22,691,921 | 250.5 kb | Distal (>10kb) Multiome | 153 | |
| chr8:22,692,857–22,693,984 | 252.5 kb | Distal (>10kb) Multiome | 490 | |
| chr8:22,694,125–22,696,129 | 254.5 kb | Distal (>10kb) Multiome | 662 |
Genomic view of the PPP3CC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.