Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ALDH3A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALDH3A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALDH3A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:19,362,100–19,363,673 | 285.9 kb | Distal (>10kb) Multiome HiCAR | 804 | |
| chr17:19,377,561–19,379,155 | 270.5 kb | Distal (>10kb) Multiome | 877 | |
| chr17:19,386,868–19,387,884 | 261.5 kb | Distal (>10kb) Multiome | 305 | |
| chr17:19,433,247–19,433,662 | 215.2 kb | Distal (>10kb) Multiome | 30 | |
| chr17:19,455,896–19,456,558 | 192.6 kb | Distal (>10kb) Multiome | 43 | |
| chr17:19,457,529–19,459,378 | 190.7 kb | Distal (>10kb) Multiome | 100 | |
| chr17:19,460,682–19,461,395 | 187.6 kb | Distal (>10kb) Multiome HiCAR | 93 | |
| chr17:19,507,283–19,508,789 | 140.6 kb | Distal (>10kb) Multiome HiCAR | 842 | |
| chr17:19,519,787–19,520,274 | 128.8 kb | Distal (>10kb) Multiome HiCAR | 130 | |
| chr17:19,533,700–19,534,412 | 114.9 kb | Distal (>10kb) Multiome | 488 | |
| chr17:19,579,724–19,580,220 | 68.9 kb | Distal (>10kb) Multiome | 101 | |
| chr17:19,645,969–19,646,517 | 2.6 kb | Proximal (<10kb) Multiome | 116 | |
| chr17:19,647,149–19,649,280 | 1.3 kb | Proximal (<10kb) Multiome | 1126 | |
| chr17:19,744,539–19,745,417 | 96.3 kb | Distal (>10kb) Multiome | 325 | |
| chr17:19,866,833–19,868,282 | 219.1 kb | Distal (>10kb) Multiome | 560 |
Genomic view of the ALDH3A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.