The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PNPLA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PNPLA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PNPLA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:42,614,291–42,616,423 | 1308.5 kb | Distal (>10kb) Multiome HiCAR | 1280 | |
| chr22:43,812,012–43,812,763 | 111.5 kb | Distal (>10kb) Multiome | 493 | |
| chr22:43,861,938–43,862,881 | 61.3 kb | Distal (>10kb) Multiome | 263 | |
| chr22:43,891,548–43,892,393 | 31.8 kb | Distal (>10kb) Multiome | 185 | |
| chr22:43,923,130–43,924,772 | 25 bp | At TSS Multiome | 741 | |
| chr22:43,925,117–43,926,046 | 1.8 kb | Proximal (<10kb) Multiome | 441 | |
| chr22:43,955,027–43,955,843 | 31.6 kb | Distal (>10kb) Multiome | 809 | |
| chr22:44,023,900–44,024,505 | 100.4 kb | Distal (>10kb) Multiome | 355 | |
| chr22:44,046,421–44,047,108 | 123.1 kb | Distal (>10kb) Multiome | 200 | |
| chr22:44,147,624–44,148,539 | 224.3 kb | Distal (>10kb) Multiome | 144 | |
| chr22:44,661,031–44,661,516 | 737.4 kb | Distal (>10kb) Multiome HiCAR | 28 | |
| chr22:44,668,163–44,669,181 | 744.8 kb | Distal (>10kb) Multiome HiCAR | 265 |
Genomic view of the PNPLA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.