This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for CHMP1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHMP1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHMP1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:89,360,791–89,361,256 | 296.7 kb | Distal (>10kb) Multiome | 194 | |
| chr16:89,473,854–89,474,466 | 183.5 kb | Distal (>10kb) Multiome | 213 | |
| chr16:89,489,154–89,489,850 | 168.4 kb | Distal (>10kb) Multiome | 596 | |
| chr16:89,490,254–89,491,281 | 167.0 kb | Distal (>10kb) Multiome | 817 | |
| chr16:89,507,395–89,509,159 | 149.4 kb | Distal (>10kb) Multiome | 987 | |
| chr16:89,560,298–89,561,204 | 97.0 kb | Distal (>10kb) Multiome | 1030 | |
| chr16:89,564,633–89,566,356 | 91.8 kb | Distal (>10kb) Multiome | 894 | |
| chr16:89,574,359–89,574,949 | 82.9 kb | Distal (>10kb) Multiome | 373 | |
| chr16:89,657,432–89,658,521 | 126 bp | At TSS Multiome | 859 | |
| chr16:89,686,359–89,687,641 | 29.1 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:89,699,933–89,702,566 | 44.3 kb | Distal (>10kb) Multiome | 1079 | |
| chr16:89,711,278–89,712,334 | 54.1 kb | Distal (>10kb) Multiome | 443 | |
| chr16:89,720,440–89,722,486 | 63.7 kb | Distal (>10kb) Multiome | 1048 | |
| chr16:89,816,022–89,817,100 | 159.0 kb | Distal (>10kb) Multiome | 995 | |
| chr16:89,827,667–89,829,190 | 170.8 kb | Distal (>10kb) Multiome | 784 | |
| chr16:89,872,618–89,874,723 | 216.5 kb | Distal (>10kb) Multiome | 1046 | |
| chr16:89,917,809–89,919,023 | 260.9 kb | Distal (>10kb) Multiome | 986 | |
| chr16:89,921,530–89,925,204 | 265.5 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:89,925,437–89,926,738 | 268.6 kb | Distal (>10kb) Multiome | 654 |
Genomic view of the CHMP1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.