The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STAT5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAT5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAT5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:40,287,308–40,288,608 | 1988.6 kb | Distal (>10kb) Multiome HiCAR | 870 | |
| chr17:42,016,953–42,018,102 | 258.9 kb | Distal (>10kb) Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 256.3 kb | Distal (>10kb) Multiome | 791 | |
| chr17:42,050,326–42,051,046 | 225.8 kb | Distal (>10kb) Multiome | 514 | |
| chr17:42,107,497–42,108,335 | 168.5 kb | Distal (>10kb) Multiome | 357 | |
| chr17:42,120,858–42,121,715 | 155.1 kb | Distal (>10kb) Multiome | 559 | |
| chr17:42,122,176–42,123,003 | 153.7 kb | Distal (>10kb) Multiome | 169 | |
| chr17:42,154,717–42,156,309 | 121.2 kb | Distal (>10kb) Multiome | 770 | |
| chr17:42,180,242–42,180,762 | 96.0 kb | Distal (>10kb) Multiome | 576 | |
| chr17:42,183,755–42,184,761 | 92.1 kb | Distal (>10kb) Multiome | 810 | |
| chr17:42,275,506–42,277,052 | 12 bp | At TSS Multiome | 892 | |
| chr17:42,288,257–42,288,808 | 12.2 kb | Distal (>10kb) Multiome | 449 | |
| chr17:42,312,237–42,312,887 | 36.1 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,387,693–42,389,289 | 112.3 kb | Distal (>10kb) Multiome | 1178 | |
| chr17:42,389,749–42,390,415 | 113.8 kb | Distal (>10kb) Multiome | 95 | |
| chr17:42,422,618–42,423,513 | 146.8 kb | Distal (>10kb) Multiome | 765 | |
| chr17:42,531,503–42,532,256 | 255.6 kb | Distal (>10kb) Multiome | 571 | |
| chr17:42,535,863–42,536,855 | 260.0 kb | Distal (>10kb) Multiome | 987 | |
| chr17:42,547,934–42,548,909 | 272.1 kb | Distal (>10kb) Multiome | 325 | |
| chr17:42,554,285–42,555,164 | 278.4 kb | Distal (>10kb) Multiome | 899 | |
| chr17:42,561,770–42,562,376 | 285.7 kb | Distal (>10kb) Multiome | 905 | |
| chr17:42,566,552–42,567,732 | 290.7 kb | Distal (>10kb) Multiome | 902 |
Genomic view of the STAT5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.