GRPR

gastrin releasing peptide receptor | BB2, BB2R, BRS2

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

Member of: DE-4 DE-4.7

Biological processes 33 terms

G protein-coupled peptide receptor activity (GO:0008528)G protein-coupled peptide receptor activity (GO:0008528)G protein-coupled peptide receptor activity (GO:0008528)G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)learning or memory (GO:0007611)membrane (GO:0016020)motor behavior (GO:0061744)motor behavior (GO:0061744)neuropeptide binding (GO:0042923)neuropeptide receptor activity (GO:0008188)neuropeptide receptor activity (GO:0008188)neuropeptide receptor activity (GO:0008188)neuropeptide signaling pathway (GO:0007218)phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200)phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of behavioral fear response (GO:2000987)positive regulation of behavioral fear response (GO:2000987)positive regulation of respiratory gaseous exchange (GO:1903942)positive regulation of respiratory gaseous exchange (GO:1903942)protein binding (GO:0005515)psychomotor behavior (GO:0036343)response to external biotic stimulus (GO:0043207)social behavior (GO:0035176)social behavior (GO:0035176)

Expression (TPM)

TFs regulating GRPR 0 TFs

Transcription factors with Perturb-seq knockdown data for GRPR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRPR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GRPR

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRPR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chrX:15,854,233–15,855,558	268.6 kb	Distal (>10kb) Multiome HiCAR	706
chrX:15,874,284–15,875,274	248.8 kb	Distal (>10kb) Multiome HiCAR	139
chrX:16,123,273–16,123,555	8 bp	At TSS	152

Genome Browser

Genomic view of the GRPR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.