This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for TCF7L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCF7L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCF7L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:112,811,603–112,812,863 | 138.1 kb | Distal (>10kb) Multiome | 494 | |
| chr10:112,832,136–112,833,093 | 117.6 kb | Distal (>10kb) Multiome | 220 | |
| chr10:112,880,869–112,881,721 | 69.0 kb | Distal (>10kb) Multiome | 159 | |
| chr10:112,898,306–112,899,885 | 51.3 kb | Distal (>10kb) Multiome | 669 | |
| chr10:112,938,485–112,939,398 | 11.3 kb | Distal (>10kb) Multiome | 120 | |
| chr10:112,949,544–112,950,439 | 172 bp | At TSS Multiome | 620 | |
| chr10:112,950,776–112,952,898 | 1.6 kb | Proximal (<10kb) Multiome | 669 | |
| chr10:112,954,976–112,955,357 | 4.7 kb | Proximal (<10kb) | 230 | |
| chr10:112,957,626–112,958,608 | 7.4 kb | Proximal (<10kb) | 257 | |
| chr10:113,053,826–113,054,510 | 103.8 kb | Distal (>10kb) Multiome | 142 | |
| chr10:113,078,444–113,078,930 | 128.5 kb | Distal (>10kb) Multiome | 63 | |
| chr10:113,126,624–113,127,043 | 2.3 kb | Proximal (<10kb) | 290 | |
| chr10:113,128,396–113,128,903 | 452 bp | At TSS | 28 | |
| chr10:113,132,657–113,132,990 | 3.3 kb | Proximal (<10kb) | 67 | |
| chr10:113,134,926–113,135,446 | 185.0 kb | Distal (>10kb) Multiome | 71 | |
| chr10:113,289,821–113,290,535 | 340.1 kb | Distal (>10kb) Multiome | 70 | |
| chr10:113,385,020–113,385,635 | 435.1 kb | Distal (>10kb) Multiome | 304 | |
| chr10:113,410,316–113,411,770 | 460.6 kb | Distal (>10kb) Multiome | 236 |
Genomic view of the TCF7L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.