This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for BCL11B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL11B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL11B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:98,210,142–98,210,692 | 1061.8 kb | Distal (>10kb) Multiome HiCAR | 118 | |
| chr14:99,142,951–99,143,625 | 128.9 kb | Distal (>10kb) Multiome | 117 | |
| chr14:99,143,710–99,144,756 | 128.2 kb | Distal (>10kb) Multiome | 200 | |
| chr14:99,230,631–99,232,582 | 40.1 kb | Distal (>10kb) Multiome | 274 | |
| chr14:99,245,498–99,247,127 | 26.2 kb | Distal (>10kb) Multiome | 314 | |
| chr14:99,262,920–99,263,579 | 9.1 kb | Proximal (<10kb) Multiome | 160 | |
| chr14:99,266,620–99,267,125 | 5.1 kb | Proximal (<10kb) | 240 | |
| chr14:99,269,934–99,270,274 | 1.9 kb | Proximal (<10kb) | 176 | |
| chr14:99,270,416–99,271,381 | 1.4 kb | Proximal (<10kb) Multiome | 301 | |
| chr14:99,271,901–99,274,036 | 1.2 kb | Proximal (<10kb) Multiome | 584 | |
| chr14:99,274,138–99,275,258 | 2.6 kb | Proximal (<10kb) Multiome | 708 | |
| chr14:99,479,847–99,482,007 | 209.0 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the BCL11B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.