Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of DNA-templated transcription; and positive regulation of autophagy. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TP53INP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TP53INP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TP53INP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:94,719,362–94,720,432 | 229.5 kb | Distal (>10kb) Multiome | 1182 | |
| chr8:94,822,329–94,823,941 | 126.2 kb | Distal (>10kb) Multiome | 818 | |
| chr8:94,894,252–94,897,051 | 53.8 kb | Distal (>10kb) Multiome | 927 | |
| chr8:94,948,413–94,950,514 | 89 bp | At TSS Multiome | 850 | |
| chr8:94,951,074–94,952,609 | 1.7 kb | Proximal (<10kb) | 142 | |
| chr8:95,024,342–95,025,424 | 75.6 kb | Distal (>10kb) Multiome | 980 | |
| chr8:95,132,764–95,134,804 | 184.4 kb | Distal (>10kb) Multiome | 917 |
Genomic view of the TP53INP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.