This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WFDC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WFDC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WFDC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:45,293,338–45,294,048 | 176.0 kb | Distal (>10kb) Multiome | 531 | |
| chr20:45,341,603–45,342,760 | 127.5 kb | Distal (>10kb) Multiome | 696 | |
| chr20:45,343,396–45,344,073 | 126.0 kb | Distal (>10kb) Multiome | 485 | |
| chr20:45,347,673–45,348,799 | 121.3 kb | Distal (>10kb) Multiome | 805 | |
| chr20:45,362,715–45,363,769 | 106.5 kb | Distal (>10kb) Multiome | 970 | |
| chr20:45,373,703–45,374,166 | 95.8 kb | Distal (>10kb) Multiome | 546 | |
| chr20:45,376,274–45,377,532 | 93.2 kb | Distal (>10kb) Multiome | 52 | |
| chr20:45,377,951–45,378,822 | 91.3 kb | Distal (>10kb) Multiome | 127 | |
| chr20:45,405,857–45,407,528 | 63.3 kb | Distal (>10kb) Multiome | 692 | |
| chr20:45,415,906–45,416,528 | 53.6 kb | Distal (>10kb) Multiome | 911 | |
| chr20:45,440,774–45,441,531 | 28.6 kb | Distal (>10kb) Multiome | 56 | |
| chr20:45,463,203–45,463,737 | 6.3 kb | Proximal (<10kb) Multiome | 34 | |
| chr20:45,469,289–45,470,949 | 92 bp | At TSS Multiome | 360 | |
| chr20:45,509,025–45,509,824 | 39.7 kb | Distal (>10kb) Multiome | 109 | |
| chr20:45,764,655–45,765,666 | 295.3 kb | Distal (>10kb) Multiome HiCAR | 192 |
Genomic view of the WFDC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.