DE-4

DE-4.4

Submodule 41 genes

Cell surface and adhesion-related genes

This module contains 41 genes including SP1, PLAUR, ETS1, MSH6, and NEDD4. Knockdown of SOX11 and SMARCC1 activates this module. Knockdown of ZNF431 represses this module.

Notable genes: SP1 PLAUR ETS1 MSH6 NEDD4 SGK3 ANO5 TNFAIP8 Top TFs: SOX11 SMARCC1 ZNF431

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding
Perturbation only
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).


Module Genes (41)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z