This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FZD8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FZD8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FZD8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:35,384,192–35,385,102 | 257.8 kb | Distal (>10kb) Multiome | 160 | |
| chr10:35,414,119–35,414,985 | 227.8 kb | Distal (>10kb) Multiome | 293 | |
| chr10:35,632,784–35,636,269 | 8.9 kb | Proximal (<10kb) Multiome | 363 | |
| chr10:35,637,054–35,637,229 | 5.1 kb | Proximal (<10kb) | 40 | |
| chr10:35,637,465–35,637,953 | 4.3 kb | Proximal (<10kb) | 71 | |
| chr10:35,638,860–35,644,220 | 17 bp | At TSS Multiome | 923 | |
| chr10:35,644,496–35,644,701 | 2.2 kb | Proximal (<10kb) | 39 | |
| chr10:35,691,528–35,692,845 | 49.7 kb | Distal (>10kb) Multiome | 232 | |
| chr10:35,770,571–35,771,511 | 128.8 kb | Distal (>10kb) Multiome HiCAR | 141 | |
| chr10:35,822,136–35,822,820 | 180.2 kb | Distal (>10kb) Multiome HiCAR | 207 | |
| chr10:35,843,567–35,844,155 | 201.6 kb | Distal (>10kb) Multiome HiCAR | 111 | |
| chr10:35,884,496–35,885,595 | 242.6 kb | Distal (>10kb) Multiome HiCAR | 242 | |
| chr10:35,912,288–35,913,062 | 270.3 kb | Distal (>10kb) Multiome HiCAR | 141 |
Genomic view of the FZD8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.