This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for EDNRA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EDNRA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EDNRA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:147,116,988–147,118,019 | 363.3 kb | Distal (>10kb) Multiome HiCAR | 207 | |
| chr4:147,480,463–147,482,217 | 352 bp | At TSS Multiome | 379 | |
| chr4:147,522,274–147,523,482 | 42.2 kb | Distal (>10kb) Multiome | 84 | |
| chr4:147,616,952–147,618,103 | 136.5 kb | Distal (>10kb) Multiome | 744 | |
| chr4:147,683,720–147,684,759 | 203.3 kb | Distal (>10kb) Multiome | 824 | |
| chr4:147,730,889–147,733,228 | 251.2 kb | Distal (>10kb) Multiome | 724 |
Genomic view of the EDNRA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.