This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for PLAGL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAGL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAGL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:143,510,987–143,512,153 | 453.2 kb | Distal (>10kb) Multiome HiCAR | 1071 | |
| chr6:143,536,309–143,537,965 | 427.6 kb | Distal (>10kb) Multiome HiCAR | 577 | |
| chr6:143,598,354–143,599,128 | 366.0 kb | Distal (>10kb) Multiome HiCAR | 303 | |
| chr6:143,677,404–143,678,655 | 286.9 kb | Distal (>10kb) Multiome | 774 | |
| chr6:143,746,106–143,747,905 | 217.4 kb | Distal (>10kb) Multiome | 594 | |
| chr6:143,842,515–143,843,902 | 121.6 kb | Distal (>10kb) Multiome | 1125 | |
| chr6:143,958,803–143,959,611 | 5.7 kb | Proximal (<10kb) Multiome HiCAR | 236 | |
| chr6:143,962,006–143,962,183 | 2.7 kb | Proximal (<10kb) | 37 | |
| chr6:143,962,620–143,962,759 | 2.1 kb | Proximal (<10kb) | 66 | |
| chr6:143,963,283–143,963,487 | 1.4 kb | Proximal (<10kb) | 59 | |
| chr6:143,964,156–143,965,374 | 65 bp | At TSS Multiome HiCAR | 218 | |
| chr6:143,969,116–143,969,594 | 4.2 kb | Proximal (<10kb) | 98 | |
| chr6:143,972,911–143,973,871 | 8.0 kb | Proximal (<10kb) | 319 | |
| chr6:144,007,258–144,007,418 | 965 bp | At TSS | 104 | |
| chr6:144,007,743–144,008,869 | 43.5 kb | Distal (>10kb) Multiome HiCAR | 500 | |
| chr6:144,013,517–144,013,734 | 5.1 kb | Proximal (<10kb) | 268 | |
| chr6:144,063,326–144,063,520 | 990 bp | At TSS | 160 | |
| chr6:144,063,633–144,064,850 | 99.3 kb | Distal (>10kb) Multiome | 823 | |
| chr6:144,094,958–144,096,613 | 130.8 kb | Distal (>10kb) Multiome | 1009 | |
| chr6:144,149,717–144,151,586 | 185.7 kb | Distal (>10kb) Multiome | 708 | |
| chr6:144,215,237–144,217,057 | 251.6 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:144,284,589–144,287,497 | 320.2 kb | Distal (>10kb) Multiome | 1050 | |
| chr6:144,330,551–144,331,098 | 365.9 kb | Distal (>10kb) Multiome | 251 |
Genomic view of the PLAGL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.