This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PLAUR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAUR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAUR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:43,463,046–43,464,465 | 206.6 kb | Distal (>10kb) Multiome | 645 | |
| chr19:43,474,993–43,475,696 | 194.8 kb | Distal (>10kb) Multiome | 506 | |
| chr19:43,503,542–43,505,032 | 165.9 kb | Distal (>10kb) Multiome | 760 | |
| chr19:43,526,489–43,527,639 | 142.9 kb | Distal (>10kb) Multiome | 712 | |
| chr19:43,532,595–43,534,553 | 136.0 kb | Distal (>10kb) Multiome | 698 | |
| chr19:43,575,342–43,576,244 | 94.5 kb | Distal (>10kb) Multiome | 562 | |
| chr19:43,580,271–43,581,020 | 89.6 kb | Distal (>10kb) Multiome | 151 | |
| chr19:43,594,710–43,596,874 | 73.9 kb | Distal (>10kb) Multiome | 998 | |
| chr19:43,618,905–43,620,391 | 50.4 kb | Distal (>10kb) Multiome | 1071 | |
| chr19:43,639,490–43,640,467 | 30.3 kb | Distal (>10kb) Multiome | 545 | |
| chr19:43,667,574–43,669,430 | 1.5 kb | Proximal (<10kb) Multiome | 787 | |
| chr19:43,669,923–43,670,430 | 1.6 kb | Proximal (<10kb) | 525 | |
| chr19:43,671,889–43,672,687 | 2.1 kb | Proximal (<10kb) Multiome | 162 | |
| chr19:43,673,253–43,674,111 | 3.7 kb | Proximal (<10kb) Multiome | 55 | |
| chr19:43,754,239–43,755,900 | 84.6 kb | Distal (>10kb) Multiome | 899 | |
| chr19:43,773,845–43,774,908 | 104.4 kb | Distal (>10kb) Multiome | 645 | |
| chr19:43,798,557–43,799,046 | 128.7 kb | Distal (>10kb) Multiome | 403 | |
| chr19:43,827,133–43,827,702 | 157.2 kb | Distal (>10kb) Multiome | 593 | |
| chr19:43,901,409–43,901,966 | 231.6 kb | Distal (>10kb) Multiome | 528 | |
| chr19:43,934,900–43,935,680 | 265.1 kb | Distal (>10kb) Multiome | 775 | |
| chr19:43,950,951–43,951,533 | 281.0 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the PLAUR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.