The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for STAT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:190,869,557–190,870,549 | 281.0 kb | Distal (>10kb) Multiome | 91 | |
| chr2:190,880,124–190,882,292 | 269.0 kb | Distal (>10kb) Multiome | 1086 | |
| chr2:191,013,523–191,014,882 | 136.7 kb | Distal (>10kb) Multiome | 1090 | |
| chr2:191,020,168–191,020,996 | 130.5 kb | Distal (>10kb) Multiome | 1169 | |
| chr2:191,049,645–191,052,413 | 100.8 kb | Distal (>10kb) Multiome HiCAR | 448 | |
| chr2:191,150,245–191,151,620 | 8 bp | At TSS Multiome | 430 | |
| chr2:191,155,578–191,156,319 | 4.9 kb | Proximal (<10kb) Multiome | 129 | |
| chr2:191,166,129–191,168,453 | 15.8 kb | Distal (>10kb) Multiome | 369 | |
| chr2:191,244,968–191,246,655 | 95.2 kb | Distal (>10kb) Multiome | 961 | |
| chr2:191,250,888–191,251,582 | 100.3 kb | Distal (>10kb) Multiome | 95 | |
| chr2:191,301,718–191,302,748 | 151.2 kb | Distal (>10kb) Multiome | 115 |
Genomic view of the STAT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.