This 18-gene module includes SMAD3, ANGPT2, SYNE1, PALLD, and SERINC5, with enriched terms related to TGF-β signaling pathway, cell-cell adhesion, and mesenchymal properties. Knockdown of EOMES, FOXA2, and SOX17 activates this module. Knockdown of NANOG, OCT4, and GATA4 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.