The protein encoded by this gene belongs to C2H2-type zinc finger family of proteins. It contains multiple C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for ZNF462. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF462 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF462, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:106,752,577–106,753,652 | 110.1 kb | Distal (>10kb) Multiome | 330 | |
| chr9:106,859,225–106,859,661 | 3.5 kb | Proximal (<10kb) | 16 | |
| chr9:106,859,773–106,864,937 | 2.9 kb | Proximal (<10kb) Multiome | 678 | |
| chr9:106,878,050–106,878,757 | 15.3 kb | Distal (>10kb) Multiome HiCAR | 154 | |
| chr9:107,028,710–107,029,579 | 166.1 kb | Distal (>10kb) Multiome | 180 | |
| chr9:107,130,867–107,131,827 | 268.1 kb | Distal (>10kb) Multiome | 242 |
Genomic view of the ZNF462 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.