ETS1

ETS proto-oncogene 1, transcription factor | ETS-1, FLJ10768, EWSR2

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Member of: DE-4 DE-4.4 Developmental clusters: GC6

Biological processes 51 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)PML body organization (GO:0030578)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)cell differentiation (GO:0030154)cell motility (GO:0048870)chromatin (GO:0000785)cytoplasm (GO:0005737)identical protein binding (GO:0042802)immune response (GO:0006955)negative regulation of cell cycle (GO:0045786)negative regulation of cell cycle (GO:0045786)negative regulation of cell population proliferation (GO:0008285)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of angiogenesis (GO:0045766)positive regulation of blood vessel endothelial cell migration (GO:0043536)positive regulation of endothelial cell migration (GO:0010595)positive regulation of erythrocyte differentiation (GO:0045648)positive regulation of gene expression (GO:0010628)positive regulation of inflammatory response (GO:0050729)positive regulation of leukocyte adhesion to vascular endothelial cell (GO:1904996)positive regulation of miRNA transcription (GO:1902895)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of angiogenesis (GO:0045765)regulation of apoptotic process (GO:0042981)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to antibiotic (GO:0046677)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription by RNA polymerase II (GO:0006366)transcription cis-regulatory region binding (GO:0000976)transcription corepressor binding (GO:0001222)

Expression (TPM)

TFs regulating ETS1 0 TFs

Transcription factors with Perturb-seq knockdown data for ETS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ETS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ETS1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ETS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:128,462,917–128,463,803	124.2 kb	Distal (>10kb) Multiome	180
chr11:128,474,645–128,475,944	112.6 kb	Distal (>10kb) Multiome	91
chr11:128,521,715–128,523,006	65.1 kb	Distal (>10kb) Multiome	613
chr11:128,532,200–128,533,780	54.6 kb	Distal (>10kb) Multiome	312
chr11:128,548,440–128,549,814	38.6 kb	Distal (>10kb) Multiome	327
chr11:128,582,760–128,583,415	4.5 kb	Proximal (<10kb) Multiome	245
chr11:128,584,124–128,584,558	3.0 kb	Proximal (<10kb)	22
chr11:128,585,760–128,586,189	1.4 kb	Proximal (<10kb)	45
chr11:128,586,297–128,586,436	1.1 kb	Proximal (<10kb)	11
chr11:128,587,463–128,587,934	at TSS	At TSS	116
chr11:128,592,321–128,592,778	4.8 kb	Proximal (<10kb)	32
chr11:128,593,081–128,594,103	5.5 kb	Proximal (<10kb)	250
chr11:128,596,185–128,596,457	8.6 kb	Proximal (<10kb)	17
chr11:128,664,272–128,664,775	76.9 kb	Distal (>10kb) Multiome	99
chr11:128,692,776–128,695,514	107.4 kb	Distal (>10kb) Multiome	466
chr11:128,733,388–128,734,413	146.3 kb	Distal (>10kb) Multiome	260
chr11:128,784,251–128,784,947	197.0 kb	Distal (>10kb) Multiome	86
chr11:128,814,988–128,815,751	227.9 kb	Distal (>10kb) Multiome	198
chr11:128,859,511–128,860,327	272.4 kb	Distal (>10kb) Multiome	299
chr11:128,871,101–128,871,739	283.7 kb	Distal (>10kb) Multiome	110
chr11:128,872,050–128,873,035	285.0 kb	Distal (>10kb) Multiome	53

Genome Browser

Genomic view of the ETS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.