This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:195,806,205–195,806,743 | 103.3 kb | Distal (>10kb) Multiome | 119 | |
| chr3:195,894,987–195,896,413 | 13.8 kb | Distal (>10kb) Multiome | 611 | |
| chr3:195,908,177–195,910,831 | 58 bp | At TSS Multiome | 661 | |
| chr3:196,081,045–196,082,675 | 172.3 kb | Distal (>10kb) Multiome | 1081 | |
| chr3:196,110,410–196,110,962 | 200.8 kb | Distal (>10kb) Multiome | 307 | |
| chr3:196,207,804–196,208,801 | 298.4 kb | Distal (>10kb) Multiome | 300 |
Genomic view of the TNK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.