This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PRKCI. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRKCI upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRKCI, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:169,966,015–169,967,550 | 255.7 kb | Distal (>10kb) Multiome | 1017 | |
| chr3:170,037,354–170,039,248 | 184.4 kb | Distal (>10kb) Multiome | 804 | |
| chr3:170,180,833–170,182,100 | 40.7 kb | Distal (>10kb) Multiome | 813 | |
| chr3:170,221,926–170,223,285 | 65 bp | At TSS Multiome | 847 | |
| chr3:170,356,326–170,358,653 | 134.8 kb | Distal (>10kb) Multiome | 971 | |
| chr3:170,418,375–170,421,188 | 196.3 kb | Distal (>10kb) Multiome | 413 | |
| chr3:170,425,589–170,426,593 | 203.7 kb | Distal (>10kb) Multiome | 432 | |
| chr3:170,476,158–170,477,136 | 254.2 kb | Distal (>10kb) Multiome | 116 |
Genomic view of the PRKCI locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.