The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, May 2022]
Transcription factors with Perturb-seq knockdown data for LMNA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMNA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMNA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:155,806,537–155,807,073 | 307.9 kb | Distal (>10kb) Multiome | 15 | |
| chr1:155,856,932–155,857,529 | 257.5 kb | Distal (>10kb) Multiome | 639 | |
| chr1:155,859,095–155,860,745 | 255.3 kb | Distal (>10kb) Multiome | 632 | |
| chr1:155,910,686–155,911,579 | 203.3 kb | Distal (>10kb) Multiome | 691 | |
| chr1:155,934,107–155,934,787 | 180.2 kb | Distal (>10kb) Multiome | 872 | |
| chr1:155,976,727–155,977,187 | 137.8 kb | Distal (>10kb) Multiome | 316 | |
| chr1:155,977,296–155,979,264 | 136.0 kb | Distal (>10kb) Multiome | 698 | |
| chr1:156,020,469–156,021,128 | 93.8 kb | Distal (>10kb) Multiome | 558 | |
| chr1:156,052,923–156,055,358 | 59.8 kb | Distal (>10kb) Multiome | 1053 | |
| chr1:156,060,806–156,061,738 | 53.5 kb | Distal (>10kb) Multiome | 318 | |
| chr1:156,063,507–156,064,184 | 50.9 kb | Distal (>10kb) Multiome | 199 | |
| chr1:156,073,800–156,074,094 | 8.8 kb | Proximal (<10kb) | 76 | |
| chr1:156,076,488–156,077,355 | 37.7 kb | Distal (>10kb) Multiome | 246 | |
| chr1:156,081,942–156,083,586 | 32.1 kb | Distal (>10kb) Multiome | 670 | |
| chr1:156,090,597–156,091,028 | 7.7 kb | Proximal (<10kb) | 334 | |
| chr1:156,105,123–156,105,479 | 9.2 kb | Proximal (<10kb) | 177 | |
| chr1:156,105,879–156,107,316 | 8.1 kb | Proximal (<10kb) Multiome | 663 | |
| chr1:156,114,184–156,115,669 | 22 bp | At TSS Multiome | 824 | |
| chr1:156,123,520–156,124,091 | 9.1 kb | Proximal (<10kb) Multiome | 679 | |
| chr1:156,129,945–156,130,610 | 15.7 kb | Distal (>10kb) Multiome | 733 | |
| chr1:156,146,058–156,146,760 | 31.6 kb | Distal (>10kb) Multiome | 429 | |
| chr1:156,149,593–156,150,242 | 35.3 kb | Distal (>10kb) Multiome | 194 | |
| chr1:156,160,602–156,161,218 | 46.4 kb | Distal (>10kb) Multiome | 218 | |
| chr1:156,181,487–156,182,119 | 67.1 kb | Distal (>10kb) Multiome | 145 | |
| chr1:156,184,002–156,185,155 | 69.7 kb | Distal (>10kb) Multiome | 216 | |
| chr1:156,193,531–156,194,375 | 79.2 kb | Distal (>10kb) Multiome | 751 | |
| chr1:156,212,611–156,213,686 | 98.4 kb | Distal (>10kb) Multiome | 893 | |
| chr1:156,245,413–156,246,269 | 131.1 kb | Distal (>10kb) Multiome | 380 | |
| chr1:156,282,165–156,283,323 | 168.1 kb | Distal (>10kb) Multiome | 973 | |
| chr1:156,291,233–156,291,857 | 176.8 kb | Distal (>10kb) Multiome | 518 | |
| chr1:156,337,825–156,339,056 | 223.8 kb | Distal (>10kb) Multiome | 836 | |
| chr1:156,356,873–156,357,393 | 242.4 kb | Distal (>10kb) Multiome | 506 | |
| chr1:156,368,893–156,369,552 | 254.5 kb | Distal (>10kb) Multiome | 529 |
Genomic view of the LMNA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.