ITGB5

integrin subunit beta 5

This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]

Member of: DE-4 DE-4.30 Developmental clusters: GC6

Biological processes 38 terms

cell adhesion mediated by integrin (GO:0033627)cell migration (GO:0016477)cell migration (GO:0016477)cell surface (GO:0009986)cell surface (GO:0009986)cell surface (GO:0009986)cell-cell adhesion (GO:0098609)cell-matrix adhesion (GO:0007160)cell-matrix adhesion (GO:0007160)cell-matrix adhesion (GO:0007160)cell-matrix adhesion (GO:0007160)endodermal cell differentiation (GO:0035987)epithelial cell-cell adhesion (GO:0090136)extracellular exosome (GO:0070062)focal adhesion (GO:0005925)focal adhesion (GO:0005925)formation of primary germ layer (GO:0001704)integrin alphav-beta5 complex (GO:0034684)integrin alphav-beta5 complex (GO:0034684)integrin binding (GO:0005178)integrin complex (GO:0008305)integrin-mediated signaling pathway (GO:0007229)integrin-mediated signaling pathway (GO:0007229)integrin-mediated signaling pathway (GO:0007229)integrin-mediated signaling pathway (GO:0007229)phagocytic vesicle (GO:0045335)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)signaling receptor binding (GO:0005102)signaling receptor complex (GO:0043235)stress fiber assembly (GO:0043149)stress fiber assembly (GO:0043149)stress fiber assembly (GO:0043149)transforming growth factor beta receptor signaling pathway (GO:0007179)transforming growth factor beta receptor signaling pathway (GO:0007179)transforming growth factor beta receptor signaling pathway (GO:0007179)wound healing, spreading of epidermal cells (GO:0035313)

Expression (TPM)

TFs regulating ITGB5 0 TFs

Transcription factors with Perturb-seq knockdown data for ITGB5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGB5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ITGB5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGB5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:124,730,263–124,730,718	156.9 kb	Distal (>10kb) Multiome	844
chr3:124,757,599–124,758,508	129.4 kb	Distal (>10kb) Multiome HiCAR	59
chr3:124,827,544–124,828,219	59.6 kb	Distal (>10kb) Multiome	128
chr3:124,886,097–124,888,040	154 bp	At TSS Multiome	804
chr3:124,888,393–124,889,745	1.9 kb	Proximal (<10kb) Multiome	135
chr3:124,910,445–124,911,085	23.4 kb	Distal (>10kb) Multiome	133
chr3:125,055,367–125,056,705	168.8 kb	Distal (>10kb) Multiome	524
chr3:125,120,569–125,121,347	233.6 kb	Distal (>10kb) Multiome	178
chr3:125,141,761–125,142,375	254.7 kb	Distal (>10kb) Multiome	228
chr3:125,155,911–125,156,374	268.7 kb	Distal (>10kb) Multiome	134

Genome Browser

Genomic view of the ITGB5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.